GenPE - Estudio de Genes Candidatos en Preeclampsia

Endothelial Nitric Oxide Synthase Genotype and Risk of Preeclampsia: a multi-centre case-control study PDF Imprimir E-Mail

Hypertension. 2004;44: 702-707.

Autores: Serrano N, Casas JP, Díaz LA, Páez MC, Mesa CM, Cifuentes Monterrosa A, Bautista A, Hawe E, Hingorani A, Vallance P, López-Jaramillo P.  


Resumen 

Background: Polymorphisms in the endothelial NO synthase (eNOS) gene have been evaluated as risk factors for preeclampsia. However, data from small studies are conflicting.  

Methods: We assessed whether eNOS genotypes alter the risk of preeclampsia in a population in which the incidence of this disorder is high. A total of 844 young pregnant women (322 preeclamptic and 522 controls) were recruited from 5 cities. Genotyping for the Glu298Asp, intron-4 and –786T3C polymorphisms in the eNOS gene was conducted. Multivariate odds ratios (ORs) were obtained to estimate the association of individual polymorphisms and haplotypes with preeclampsia risk.  

Results: No increase in the risk of preeclampsia for the intron-4 or –786T3C polymorphisms was observed under any model of inheritance. In contrast, in women homozygous for the Asp298 allele, the adjusted OR for preeclampsia was 4.60 (95% confidence interval [CI], 1.73 to 12.22) compared with carriers of the Glu298 allele. After a multivariate analysis, carriage of the “Asp298–786C-4b” haplotype was also associated with increased risk of preeclampsia (OR, 2.11 [95% CI, 1.33 to 3.34]) compared with carriers of the “Glu298–786T-4b” haplotype. 

Conclusion: The eNOS Glu298Asp polymorphism and the Asp298–786C-4b haplotype are risk factors for preeclampsia.


Descargar Aquí

 

Lenguaje

EnglishEspañol

Centro Coordinador

Advertisement

Alianzas Internacionales

Image
University College London
 

Image

London School of Hygiene & Tropical Medicine

 

Buscador GenPE

Ubicación :Inicio arrow Quienes Somos arrow Publicaciones arrow Publicaciones Internacionales arrow Endothelial Nitric Oxide Synthase Genotype and Risk of Preeclampsia: a multi-centre case-control study
UPBUISUniCartagena Image ImageImage  Image Image 

 UPB

 UIS

 Unicartagena

 CES

 FUCS

UNIVALLE

 HUV

PROLAB