GenPE - Estudio de Genes Candidatos en Preeclampsia

A Polymorphism in the human CRP gene influences basal and stimulated CRP levels: implications for the prediction and pathogenesis of coronary heart disease PDF Imprimir E-Mail

Arterioscler Thromb Vasc Biol. 2003;23(11): 2063-2069.

Autores: Brull DJ, Serrano N, Zito F, Montgomery HE, Rumley A, Sharman P, Lowe GDO, World MJ, Humphries SE, Hingorani AD.

Resumen:

Objective: C-reactive protein (CRP) concentrations are predictive of cardiovascular disease, and levels are heritable, in part. We identified novel polymorphisms in the CRP gene and assessed their influence on CRP level.  

Methods: CRP was measured in 250 male army recruits before and after strenuous exercise and perioperatively in 193 coronary artery bypass graft (CABG) patients. Two novel polymorphisms were identified in the CRP gene, _717G_A in the promoter and _1444C_T in the 3_UTR.  

Results: Among army recruits, CRP was higher in _1444TT homozygotes than _1444 C-allele carriers at baseline (1.04_0.38 versus 0.55_0.06, P_0.014) and at all time points after exercise (2.35_0.68 versus 1.07_0.12, 2.11_0.53 versus 0.88_0.09, and 1.77_0.44 versus 0.71_0.09, P_0.034, P_0.007, and P_0.013, at 2, 48, and 96 hours after exercise, respectively). In the CABG patients, mean CRP (mg/L) rose from 1.97_0.36 at baseline to 167.2_5.0 72 hours postoperatively. Genotype did not influence CRP at baseline; however, peak post-CABG CRP levels were higher in _1444TT homozygotes compared with _1444C-allele carriers (198_17 versus 164_5, P_0.03).  

Conclusions: The CRP gene _1444C_T variant influences basal and stimulated CRP level. These findings have implications both for the prediction and pathogenesis of coronary heart disease. 


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